Charles River Seminar 2025
Jean Cozzi, PhD.
Innovation Manager. Genetically Engineered Models and Services, Charles River Laboratories.
Theatre room, CiMUS
About
This Charles River seminar highlights the importance of genetic standardisation in research mice and how undetected genetic heterogeneity can impact the reproducibility of studies. It reviews common causes of variability and molecular analysis techniques like SNPs and STRs. The session also explains how mouse nomenclature reveals key information about a strain's origin and genetic traits. Understanding this nomenclature is essential for selecting appropriate models and controls in research.
PROGRAMME
09:30 - 10:30 h. Genetics of Research Mice: from Fiction to Facts
Inbred mice have historically been essential models for scientific research and will continue to be so. Indeed, genetic standardisation plays a key role in reducing variances within study populations, it facilitates both the monitoring of therapeutic efficacy and reduces differences between studies in order to maximize reproducibility of results. However, recent studies have revealed that a high proportion of inbred mouse lines are genetically heterogenous populations. Genotyping inconsistencies, wrong colony management practices and lack of genetic testing controls all lead to poor mouse model genetic standardisation. This presentation will review how genetic background heterogeneity may arise within a colony, and what molecular testing approaches such as polymorphic markers analysis (SNPs and STRs), really tell us about mouse genetics.
10:30- 11:30 h. What's in a Name? Understanding the Basics and Research Value of Mouse Nomenclature
Mouse nomenclature can be used to determine a strain’s genetic background, genetic modifications, who generated it, and who currently distributes it. Understanding mouse nomenclature also enables you to select optimal mouse models and control strains for your research, and generates the most reliable and reproducible data.
In this seminar learn about:
• Interpreting the nomenclature of inbred, mutant, and genetically modified mouse strains
• How quickly substrains develop and affect research results
• The impact of genetic background on strain phenotypes
• Considerations for selecting control mice
Registration is free, but mandatory as seats are limited.
Please do so here if you are interested: https://www.criver.com/education-training/ev-reg-rm-charles-river-seminar-062425-cimus
Hosted by PI Anxo Vidal