Deciphering the trajectory of hepatic stellate cell differentiation to understand fibrosis

About
Hepatic stellate cells (HSCs) are the main fibrogenic cell type in the liver and an excellent model for investigating fibrosis. In this talk, I will share our work on using induced pluripotent stem cells (iPSCs) to explore the commitment of HSCs, the mechanisms underlying their identity acquisition, as well as the role of these mechanisms in liver fibrosis. 

Bio
Pau Sancho-Bru is Group Leader at IDIBAPS and Associate Professor at University of Barcelona. He obtained his PhD degree at the University of Barcelona in 2006. In 2007 he joined the Stem Cell Institute Leuven at KULeuven, Belgium, as a postdoctoral researcher. In 2017, he was appointed Group Leader at IDIBAPS, where his group is conducting translational research in chronic liver disease and carcinogenesis. His group is interested in understanding the liver cell plasticity and regeneration in chronic liver disease and the interplay of these processes with liver inflammation and fibrosis. In this context, one of the main research interests of his group is developing stem cell-based  organotypic in vitro systems for disease modeling and drug development.

Hosted by Rubén Nogueiras. Molecular Metabolism Group, CiMUS

Certificates of attendance will be provided upon request at cimus.xestion [at] usc.es (cimus[dot]xestion[at]usc[dot]es). Please do not forget to enter your name and surname in the printout given during the lecture.