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CiMUS Seminar

"Decoding the epitranscriptome and its dynamics at single molecule resolution"

Eva Maria Novoa

Group Leader "Epitranscriptomics and RNA Dynamics", Center for Genomic Regulation (CRG), Barcelona.

22 July 2022 13:00–14:00

Theatre Room, CiMUS

About:

The dynamic deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial accurate gene expression programs. A major difficulty in studying these modifications, however, is the need of tailored protocols to map each RNA modification individually. In this context, direct RNA nanopore sequencing (dRNA-seq) has emerged as a promising technology that can overcome these limitations, as it is in principle capable of mapping all RNA modifications simultaneously, in a quantitative manner, and in full-length native RNA reads.  Here I will present the latest work on how we can use dRNA-seq to identify RNA modifications with single nucleotide and single molecule resolution, to then study the biological functions and dynamics of the epitranscriptome, their interplay with other regulatory layers, as well as to decipher how and why epitranscriptomic dysregulation is often associated to human disease.

Bio:

Eva Maria obtained her BSc in Biochemistry in 2007 and PhD in Biomedicine in 2012 in Barcelona (Spain). She is Group Leader of the ?Epitranscriptomics and RNA Dynamics? laboratory at the Center for Genomic Regulation (CRG) in Spain. Her lab is focused on deciphering the language of RNA modifications, and how its orchestration can regulate our cells in a space-, time- and signal-dependent manner. Eva Maria?s work has been awarded grants from ERC (2021), AECC (2021), MERCK (2021), MICINN (2018), ARC (2018), HFSP (2014), EMBO (2013) and LaCaixa (2008). She has been awarded the Young Researcher Prize from the Catalan Society of Biology (2018) as well as the Fisher Scientific Prize from the Spanish Society of Molecular Biology and Biochemistry (2013), among others.

Hosted by PI Diana Guallar (Epitranscriptomics and Ageing Group)

Attendance certificates will be provided upon request to cimus.xestion [at] usc.es. Please bear in mind to register by writing clearly the name and surname on the printed sheet. We will not be responsible for amending the records of anyone who fails to do so.