CiMUS Seminar

The genomic outcomes of DNA breakage and chromosome fragmentation

Cheng-Zhong Zhang, Ph.D.

Assistant Professor of Biomedical Informatics, Dana-Farber Cancer Institute. Harvard Medical School. USA.

21 September 2026 13:00–14:00

Theatre room, CiMUS + ZOOM

About
Different rearrangement outcomes of DNA double-strand breakage and chromosome fragmentation will be describe, with a focus on their connections to DNA end processing, replication, and ligation. The talk will then discuss how the rearrangement and copy-number signatures of DNA breakage and chromosome fragmentation can explain cancer genome complexity.

Bio
Cheng-Zhong is Assistant Professor at Harvard Medical School and leads a research group in the Department of Data Science at Dana-Farber Cancer Institute, with an affiliation with the Broad Institute of MIT and Harvard. His work focuses on understanding how complex chromosomal alterations arise and shape cancer genome evolution, combining single-cell genomics and experimental cell biology. He is particularly well known for his contributions to the biological mechanisms of chromothripsis, including landmark work linking DNA damage in micronuclei to catastrophic chromosome rearrangements.

If you want to attend virtually, register in advance for this meeting:

https://us02web.zoom.us/meeting/register/Jzi_Xz5zR_26ceZDNBUR3w

After registering, you will receive a confirmation email containing information about joining the meeting.

Hosted by PI Jose Tubío. Mobile Genomes Group, CiMUS

Certificates of attendance will be provided upon request at cimus.xestion [at] usc.es (cimus[dot]xestion[at]usc[dot]es). Please do not forget to enter your name and surname in the printout given during the lecture.