Happy Thursdays with Teresa & Nicolò

Exploring the role of p107 in pancreatic function during type 2 diabetes

Retinoblastoma (Rb) and their related Rb-like 1/p107 proteins play for pancreatic function modulation. My research aims to explore the specific role of these proteins, especially p107, in beta cell metabolism and its consequences for the development of type 2 diabetes (T2D). Currently, we are using islets of wild-type and whole-body p107 knockout mice models with T2D, as well as beta cell lines, to study our hypothesis. 

CV highlights: 

Ana Teresa Brito Maduro is a PhD student from Porto University, doing part of my thesis in CiMUS with a FCT fellowship (fellowship from the Portuguese government).  She has 2 papers as first author and a few attending communications in national and international congresses. Since her master’s thesis, she is interested in studying the mechanisms of insulin resistance in pancreatic beta cells and how cellular senescence can modulate it. 

Teresa Maduro. PhD student, Diabesity group, (P0L3), CiMUS

Polyphosphazene‑based nanocomplexes for mRNA delivery: therapeutic potential in glioblastoma combined with radiotherapy

Polyphosphazene-based nanocomplexes were developed for mRNA delivery in glioblastoma. The system showed good physicochemical properties, stability, and in vitro transfection efficiency. In an orthotopic GBM model, IL-12 and CXCL9 mRNA combined with radiotherapy improved survival and immune infiltration. These results support PPZ nanocomplexes as a promising mRNA-based immunotherapy platform.

CV highlights:

Nicolò Della Bona is a PhD student in Pharmaceutical Nanotechnology at CiMUS, University of Santiago de Compostela (Spain). He holds a master’s degree in Pharmaceutical Chemistry and Technology at the University of Pisa (Italy) and carries out his research within the Biomaterials & Drug Delivery group, focusing on polymer-based nanocomplexes and mRNA delivery for brain cancer therapy.

Nicolò Della Bona. PhD student at the Biomaterials & Drug Delivery Group (P2L6), CiMUS. 

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