"On the machines that make and repair our chromosomes"
Dana Branzei
Principal Investigator at IFOM (Istituto FIRC di Oncologia Molecolare, Milano), Italy
Theatre Room, CiMUS
About:
In this talk, Dana will first review our current understanding on how replisome components contribute to DNA repair during genome replication. Dana will then present new findings in the lab pertaining to the mechanism by which replisome components facilitate sister chromatid cohesion, a process linked to genome replication and providing structural dimension and strength to chromosomes.
Bio:
Dr. Branzei's lab combines visualization of DNA repair and replication intermediates with the mechanistic characterization of complex processes using genomics, genetics and biochemistry. On top of her outstanding publications, her scientific leadership has been internationally acknowledged by her election as an EMBO member and the awards of two prestigious research grants from the European Research Council - Starting (2009-2014) and Consolidator (2016-2021)-, along with multiple national grants.
Host PI: Miguel González Blanco. DNA Repair and Genome Integrity Group, CiMUS