'Metabolic adaptation as a defence strategy against infection'

Pathogenic organisms exert a negative impact on host health and fitness. Host immunity limits negative impact of infection through resistance mechanisms that sense and target pathogens for containment, killing or expulsion. Protection from infection however, requires an additional defense strategy provided by tissue damage control mechanisms. These adjust the metabolic output of host tissues to different forms of stress and damage associated with infection, establishing disease tolerance to infection. In this talk, he will explore how host metabolic adaptation contributes to the establishment of disease tolerance to infection.

About

Dr. Miguel Parreira Soares obtained his BS in biology (1990), MS in cellular biology (1994) and Ph.D. in Science (1995) from the University of Louvain in Belgium. He was research fellow with Prof. Fritz H. Bach (1995-1998), instructor in surgery (1998‑2004) and lecturer (2003‑2004) at the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, (USA). Since 2004, he is Principal Investigator at Instituto Gulbekian de Ciência, in Oeiras, and invited professor at Lisbon Medical School, "Faculdade de Lisboa", both in Portugal. The research developed by Miguel Soares laboratory aims at understanding the cellular and molecular mechanisms regulating inflammation and immunity and how these can be targeted therapeutically to overcome the pathologic outcome of immune mediated inflammatory diseases.