'Molecular control of stem cell and developmental potency'

Molecular control of the pluripotent state in embryonic stem cells resides in a core circuitry of master transcription factors OCT4, SOX2 and NANOG that act in conjunction with epigenetic cofactors for activation and repression of downstream target genes. I will summarize our major findings of a few novel factors for their roles in controlling pluripotency, reprogramming, and early developmental potency.

About

As Principal Investigator on numerous New York state and National Institutes of Health -funded stem cell grants, I laid the groundwork in applying genomic and proteomic approaches in dissecting molecular mechanisms underlying both maintenance and establishment of pluripotency as well as early developmental potency. This has led to a number of high impact studies from my lab published in PNAS (2012), Nature (2013), Cell Stem Cell (2015; 2016), Molecular Cell (2014), Cell Reports (2017), eLIFE (2017), Nature Genetics (2018).