Neuronal responses to bacterial signals

About
Having investigated the mechanisms by which gut bacterial compound may influence brain functions and its downstream effects, we showed that muropeptides mediate a direct microbiota-brain neuron communication via the Nod2 receptor in a sex- and age-biased way. Using 3D brain imaging and hormonal alterations in mice, we revealed the influence of sex hormones on the gut-brain communication. 

Bio
Ilana Gabanyi studies the interactions between gut-bacterial signal and brain neurons.  She demonstrated that microbe-derived muropepetides are found in the brain and alter neuronal activity, with some of these interactions being sex- and age-dependent. Now her team is exploring the impact of sex hormones on gut-brain communication and other behaviour phenotypes driven by brain neuronal sensing of muropeptides. .

Hosted by PI Alba Vieites Prado. Brain Plasticity Group, CiMUS

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