p53 and metaflammation in metabolic disease
Andreas Prokesch
Group leader, Gottfried Schatz Research Centre for Cell Signalling, Metabolism and Aging, Medical University of Graz, Austria
Theatre Room, CiMUS
About:
Metaflammation, the obesity-associated inflammation of metabolic tissues, is a hallmark of the metabolic syndrome. In particular, adipose tissue (AT) and liver show a high fluctuation of innate and adaptive immune cells upon weight gain or loss. We investigate lipid-associated macrophages in AT and liver in the development of metabolic derangements and focus on p53 signalling in parenchymal cells as a regulator of metaflammation during fasting as weight loss intervention.
Bio:
Research focus: Mechanisms of fasting in metabolic disease and cancer
Master thesis: National Institute of Health (NIH), Bethesda, USA
Doctoral thesis: Graz University of Technology, Austria
Postdoc time: University of Pennsylvania, Philadelphia, USA
Current position: Group leader, Gottfried Schatz Research Centre for Cell Signalling, Metabolism and Aging, Medical University of Graz, Austria
Host PI: Rubén Nogueiras. Molecular Metabolism Group, CiMUS
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