"PET imaging of functional P-gp at the blood-brain barrier; from Basics to Clinical Applications"
Gert Luurtsema
Associate Professor. Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen (University of Groningen, The Netherlands)
Theatre Room, CiMUS
About:
This presentation will inform the audience about the development of a PET method to measure the P-glycoprotein function at the blood-brain barrier in vivo; from basics to clinical applications.
P-glycoprotein is an efflux transporter and plays an important role in drug resistance and in several brain disorders like Alzheimer's or Parkinso's disease. The rationale of this research, the used techniques to develop this in vivo PET method, and recent data derived from pre-clinical and clinical PET studies will be shared with the audience.
Bio:
Gert Luurtsema, associate professor, P.I., Ius promovendi, and appointed as clinical radiochemist at department of Nuclear Medicine and Molecular Imaging (NMMI). His research focused on from tracer development to validation of clinical imaging applications. He is supervising > 10 PhD students and several master students. Currently, he has > 100 peer-reviewed scientific articles in high-ranking journals and is board member of several committees, like European Association of Nuclear Medicine (EANM) pharmaceutical science committee.
Hosted by PI Pablo Aguiar (Molecular Imaging Biomarkers and Pharmacokinetic Modelling Group)
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