Regnase-1 is an endoribonuclease involved in destabilization of a variety of mRNAs including IL-6 and Regnase-1 itself mRNAs. Regnase-1 knockout mice show generalized inflammation. Rengase-1 is phosphorylated by a variety of stimuli. We generated a variety of tissue-specific KO mice and phosphorylation-resistant knock-in mice. I will talk about the role of Regnase-1 in various cells and tissues.
Professor Shizuo Akira studied IL-6 gene regulation and signalling and cloned transcription factors, NF-IL6(C/EBP beta) and STAT3. Later, by generating TLR family knockout mice, he identified ligands of many TLR members. He also demonstrated that the difference in signalling pathway among TLRs is due to selective usage of adaptor molecules such as MyD88 and TRIF. He demonstrated that pathogen-derived RNA is recognized by cytoplasmic receptor family, besides TLRs, and clarified the molecular mechanism of antiviral response against RNA viruses. His research interests are molecular mechanisms of innate immunity and inflammation, which are studied mainly by generating knockout mice.
During the last ten years, he has been studying the function of genes which are rapidly induced in response to TLR ligands by generating knockout mice. This research has moved his interest to two topics, one is the role of mRNA stability/destabilization in the immune response, and the other is the identification of macrophage/monocyte subsets involved in different biological phenomena.
He has contributed numerous research articles receiving 435,543 citations, h-Index=298.
Host: Manuel Collado.
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