Protein modification by ubiquitin is one of the most important post-translational modifications, controlling virtually every process in eukaryotic cells. The human genome codes for more than 600 ubiquitin E3 enzymes, which confer substrate specificity. Determining E3-to-substrate wiring is a challenge, which we aim to address in the context of genome biology and human disease.
Román González-Prieto has recently started in CABIMER the ubiquitin signaling and proteomics group to study the role of ubiquitin(-like) modification in genome biology and human disease. Roman has made several contributions to the Ubiquitin(-like) field, including the E3-specific SUMO proteome (Salas-Lloret et al. 2023 Sci Adv) or the role of the tumor suppressor BRCA1/BARD1 E3 in DNA replication. Salas-Lloret et al. 2023 under review).
Host: Clara Álvarez.
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