'Unravelling a role for the NAD+-dependent deacetylase Sirtuin 2 in metabolic regulation'

Abstract:

Pedro Gomes is studying the role of mammalian sirtuins, a class of NAD⁺-dependent histone/protein deacetylases, in metabolic regulation, particularly in the setting of obesity and diabetes. Recent data suggest that an understudied isoform, sirtuin 2, regulates several metabolic pathways, including hepatic insulin sensitivity and lipid metabolism, and may represent a potential target to counteract metabolic disease.

Bio:

Pedro Gomes obtained his PhD in Human Biology at the University of Porto. He did postdoctoral studies at UCLA (US) and later at the University of Minho. He was then hired as Assistant Researcher at the University of Porto and later at the Center for Neuroscience and Cell Biology, University of Coimbra. As a consequence, he has obtained a multidisciplinary background in several disciplines (Pharmacology, Physiology, Endocrinology and Aging) and a broad set of skills in cellular and animal models. His current research interests are focused on the role of mammalian sirtuins on cardiometabolic disorders.