Marcos Fernández Fondevila & Cristina Riobello

Role of CPT1A in the activation of hepatic stellate cells and fibrosis

The pathogenesis of liver fibrosis requires the activation of hepatic stellate cells (HSCs); once activated, HSCs lose intracellular fatty acids but the contribution of fatty acid oxidation and carnitine palmitoyltransferase 1A (CPT1A) in this process remained unexplored. We show that CPT1A in HSCs is elevated in patients and mice models with fibrosis and that the manipulation of CPT1A regulates the metabolic and fibrogenic activation phenotype.

Marcos Fernández Fondevila is currently holding a Xunta-Fulbright postdoctoral fellowship at Diéguez lab (P0L3), CiMUS. Before, he carried out his PhD degree in Endocrinology (FPU predoctoral fellowhsip) at Nogueiras' lab, also at CiMUS. His main research interests are liver metabolism, metabolic and fibrotic control of stellate cells in chronic liver disease. His profile summary can be : 14 publications (first author in 4, co-first author in 2), average IF(5Y)=18.0, number of citations=194, h-index=8.

Marcos Fernández Fondevila

Functional Obesomics Group

Metabolic Adaptation in Liver Regeneration

In clinical situations, the survival of the patient after tumor resection or orthotopic liver transplantation is clearly determined by the ischemic damage suffered by the organ during the surgery and by its intrinsic capacity to regenerate. In this work, we seek to provide a comprehensive view of the regenerating liver at single-cell resolution of differential populations of cells in normal and steatotic livers.

Cristina Riobello completed her doctoral thesis at the Health Research Institute of Asturias, ISPA, studying the genomic context of the different types of sinonasal cancer. She is currently a Postdoctoral Bioinformatician in the Gene Regulatory control in Disease group (P1L8) at CiMUS.

Cristina Riobello Suárez

Gene Regulatory control in Disease Group