Cell Signalling and Stress (Cell Stress lab)

We are interested in understanding how cells respond to stress to keep the whole organism homeostasis and what can go wrong with this response in several pathologies. We are mainly focused on the characterization of the cell responses that happen after the activation of the GCKIII proteins of the Ste20 group of kinases. In doing so we and others have seen that these kinases are implicated in regulating cell metabolism and in the orderly development of the microvasculature in stressful situations. At present, we are studying the implication of GCKIII in the alteration of the microvasculature of the central nervous system as it is the case in the cerebral cavernous malformation disease and in the resistance to insulin and the alterations that follow in the liver.