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Programa de Mecanismos Moleculares | Cancro

Virus and Cancer (VICA)

Carmen Rivas Vázquez
Carmen Rivas Vázquez
Group Leader | CSIC head scientist
mcarmen.rivas@usc.es
ORCID: 0000-0002-0518-7199
 
Lab: P1L7
Área de coñecemento

Our interest is the study of the virus-host cell interaction, and the contribution of ubiquitin-like proteins to this interplay. 

Liñas de investigación

We have two fundamental lines of research: 

  • The study of the exploitation of cellular machinery by viruses in order to favor their replication.
  • The study of the cellular molecular pathways relevant for the control of viral replication and cell proliferation. 

We are especially interested in the role that small ubiquitin-like proteins (SUMO) play in both processes. Our aim is to identify those mechanisms that regulate both viral replication and the development of proliferative diseases, to expand the knowledge of the relationship between viruses and cancer and to discover potential prophylactic or therapeutic targets for intervention.  

Membros

 

Yanis Hichem Bouzaher
PhD student
María Blanquer Gárate
PhD student
Beatríz Rodríguez Lemus
PhD student
Rocío Miranda Tolosa
PhD student

Publicacións seleccionadas

SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation

Ahmed El Motiam, Yanis H. Bouzaher, Haifen Chen, Rocío Seoane, Santiago Vidal, María Blanquer, Rocío M. Tolosa, Beatriz Rodríguez-Lemus, José A. Herrera-Gavilán, Anxo Vidal, Ignacio Palmero, Manuel S. Rodríguez, James D. Sutherland, Rosa Barrio, Dimitris Xirodimas, Manuel Collado, Rod Bremner & Carmen Rivas
Cell Death Dis 16, 519 (2025)

eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production.

R Seoane, Y T Llamas-González, S Vidal, A E Motiam, Y H Bouzaher, D Fonseca, R Farrás, A García-Sastre, J González-Santamaría, C Rivas.
Front Cell Infect Microbiol 2022; 12:960138.

SUMOylation modulates the stability and function of PI3K- p110 beta.

A E Motiam, C F de la Cruz-Herrera, S Vidal, R Seoane, M Baz-Martínez, Y H Bouzaher, E Lecona, M Esteban, MS Rodríguez, A Vidal, M Collado, C Rivas
Cell Mol Life Sci. 2021 Apr;78(8):4053-4065.

Expression of the Ebola Virus VP24 Protein Compromises the Integrity of the Nuclear Envelope and Induces a Laminopathy-Like Cellular Phenotype.

S Vidal, M Sánchez-Aparicio, R Seoane, A E Motiam, E V Nelson, Y H Bouzaher, M Baz-Martínez, I García-Dorival, S Gonzalo, E Vázquez, A Vidal, C Muñoz-Fontela, A García-Sastre, C Rivas.
mBio. 2021 Aug 31;12(4):e0097221.

Regulation of the Ebola Virus VP24 Protein by SUMO

Santiago Vidal, Ahmed El Motiam, Rocío Seoane, Viktorija Preitakaite, Yanis Hichem Bouzaher, Sergio Gómez-Medina, Carmen San Martín, Dolores Rodríguez, María Teresa Rejas, Maite Baz-Martínez, Rosa Barrio, James D Sutherland, Manuel S Rodríguez, César Muñoz-Fontela, Carmen Rivas
JOURNAL OF VIROLOGY, JAN 2020

Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function

El Motiam, A; Vidal, S; de la Cruz-Herrera, CF; Da Silva-Alvarez, S; Baz-Martinez, M; Seoane, R; Vidal, A; Rodriguez, MS; Xirodimas, DP; Carvalho, AS; Beck, HC; Matthiesen, R; Collado, M; Rivas, C
FASEB JOURNAL, 2019 Jan;33(1):643-651
Cell senescence is an antiviral defense mechanism.
Baz-Martínez M, Da Silva-Álvarez S, Rodríguez E, Guerra J, El Motiam A, Vidal A, García-Caballero T, González-Barcia M, Sánchez L, Muñoz-Fontela C, Collado M, Rivas C.
Sci Rep. , 2016 Nov 16;6:37007.

Resultados seleccionados

Proxectos

Proxecto(s) activo(s)

Proxectos nacionais

CONSOLIDACIÓN E ESTRUTURACIÓN 2023 GRC GI-2119 - Mecanismos Moleculares de la Enfermedad - MeMoEn
REF: ED431C 2023/10Duration: -
PI: Juan Bautista Zalvide Torrente
AXENCIA GALEGA DE INNOVACION (GAIN)
Ubiquitin-like proteins in virus-host cell interaction.
REF: PID2021-126510NB-I00Duration: - AGENCIA ESTATAL DE INVESTIGACION
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Proyectos de Generación de Conocimiento 2021.

Proxecto(s) finalizado(s)

Outros proxectos internacionais

A sound proteome for a sound body: targeting proteolysis for proteome remodeling (ProteoCure)
REF: CA20113Duration: -
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COST Action.

The ProteoCure COST Action aims at fostering research and innovation in the field of proteolysis with the goal of manipulating the proteolysis machinery for the development of novel, specific and efficient therapies.
ProteoCure will gather European researchers from the academic, clinical, and industry sectors, interested to develop a knowledge-based network fostering research on this issue. By organizing community-building activities, fostering synergies among European scientists and reinforcing the training of the next generation of European researchers, the Action will allow creation of a large and creative exchange hub focusing on normal and pathologic proteolysis, and on the development of innovative tools modulating the level of specific protein(s). The final aim is to facilitate the translation of novel discoveries into products of clinical and/or economical value.

 

Proxectos nacionais

Modulación por SUMO de rutas de señalización celular y replicación viral. EXCELENCIA 2017
REF: BFU2017-88880-PDuration: -
PI: María del Carmen Rivas Vázquez
AGENCIA ESTATAL DE INVESTIGACION