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New Medicines

Biomaterials & Drug Delivery (BIDD)

Marcos García Fuentes
Group leader | Associate Professor
marcos.garcia@usc.es
 
Field of knowledge

Gene, tissue engineering and cell therapies are considered by EU directives as the current line of advanced therapy medicinal products. Our research focuses on providing new functional biomaterial and nanomedicine platforms to support these new therapies. Concretely, our platforms are engineered to overcome important bottlenecks on targeting, kinetics, efficacy and bioactivity of these therapeutics, which limit their clinical translation. Current platforms from the BIDD group include a range of nanocarriers for gene and protein delivery, microspheres for sustained protein release, and gene activated matrices.

Research Lines

  • Gene nanomedicines based on stimuli-sensitive polyphozphazenes.
  • Nanomedicines based on natural and biosynthetic proteins
  • Transcription activated matrices

Members

 

Sara Gutiérrez Gutiérrez
PhD Student
Rocío Mellid Carballal
FPU fellowship
Raquel Martínez Campelo
Xunta de Galicia fellowship
Diego Gallego Barrios
PhD student

Selected publications

Structure-Optimized Interpolymer Polyphosphazene Complexes for Effective Gene Delivery against Glioblastoma

Hsu, W.H.; Sánchez-Gómez, P; Gomez-Ibarlucea, E; Ivanov, D. P.; Rahman, R; Grabowska, Anna M.; Csaba, N; Alexander, C; Garcia-Fuentes, M.

Co-delivery of RNAi and chemokine by polyarginine nanocapsules enables the modulation of myeloid-derived suppressor cells

Ledo, AM; Sasso, MS; Bronte, V; Marigo, I; Boyd, BJ; Garcia-Fuentes, M; Alonso, MJ

mRNA-activated matrices encoding transcription factors as primers of cell differentiation in tissue engineering

Ledo AM, Senra A, Rilo-Alvarez H, Borrajo E, Vidal A, Alonso MJ, Garcia-Fuentes M

Extracellular matrix mechanics regulate transfection and SOX9-directed differentiation of mesenchymal stem cells.

Ledo, A.M., Vining, K.H., Alonso, M.J., Garcia-Fuentes, M., Mooney, D.J.

Selected Results

The BiDD research group has made instrumental in developing advanced drug delivery systems and applications of nanotechnology in medicine. Over the past years, their focus has been on creating novel therapeutic systems that can modify the cellular environment in pathologies such as cancer.

Key Research Areas and Achievements:

  1. Nanocapsules for Enhanced Anticancer Therapies: The group developed specialized nanocapsules targeting lymphatic nodes. This technology significantly improves the delivery and efficacy of anticancer drugs.
  2.  Advanced Treatment Approaches for Glioblastoma: Garcia-Fuentes and his team have created implantable systems loaded with bone morphogenetic proteins. These systems are designed to induce differentiation in glioblastoma initiating cells, offering a new approach to treating this aggressive form of brain cancer.
  3. Gene Delivery Systems: The team has innovated in the field of gene therapy by developing click-able polyphosphazenes. This advancement has substantially improved the efficiency of gene delivery systems. Novel viromimetic particles are under development.
  4.  Immunotherapy Technologies: A significant achievement includes designing nanocapsules for the dual delivery of chemokines and RNA. This approach targets immunosuppression in cancer therapy, opening new avenues in immunotherapy.
  5. Tissue Engineering and Repair: They have pioneered mRNA activated matrices for tissue engineering. These matrices are activated with messenger RNA encoding transcription factors, a novel approach in tissue repair and regeneration.

Projects

National project(s)

Infection-mimicking mRNA matrices (IMMMA)
REF: PID2021-124986OB-I00Duration: -
PI: Marcos García Fuentes
AGENCIA ESTATAL DE INVESTIGACION

Alliances

EuroNanoMed

Patents

Partículas purificadas de polen y su uso para administrar nanosistemas
Aplication Nº: P201730151
N. Csaba, D. Pan Delgado, S. Reimondez Troitiño, M. García Fuentes
Partículas purificadas de polen, procedimiento y su uso para administrar nanosistemas
Aplication Nº: P201730152
N. Csaba, D. Pan Delgado, S. Reimondez Troitiño, M. García Fuentes
Polímeros para Terapia Génica
Aplication Nº: ES2809348 B2
C. García Mazás, N. Csaba, M. García Fuentes
Partículas purificadas de polen y su uso para administrar nanosistemas
Aplication Nº: ES2613585 B2
Nanocápsules with a polymeric cover
Aplication Nº: P201130015
Alonso M.J., Torres D., García Fuentes M., Rivera G.R., Oyarzún F., Gonzalo T., Lollo G.
Chitosan and ciclodextrine nanoparticles
Aplication Nº: P200501331 Licenced.
Alonso M.J., García Fuentes M., Maestrelli F., Mura P.
Controlled release formulation
Aplication Nº: WO2014044894 (A1)
M. García Fuentes, E. Reguera Núñez, N. Csaba
Biodegradable scaffold comprising messenger RNA
Aplication Nº: P201630565; PCT/ES2017/070262
M. García Fuentes, A. Martinez Ledo, A. Vidal Figueroa
Controlled release formulation
Aplication Nº: WO2014044894A1
Marcos García Fuentes, Elaine Reguera Núñez, Noemi Csaba
Biodegradable scaffold comprising messenger RNA
Aplication Nº: P201630565
M. García Fuentes, A. Martinez Ledo, A. Vidal Figueroa