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Mechanisms of Disease

Cell Signalling and Stress (Cell Stress lab)

Celia María Pombo Ramos
Group Leader | Full professor
Lab: P1L6
Field of knowledge

We are interested in understanding how cells respond to stress to keep the whole organism homeostasis and what can go wrong with this response in several pathologies. We are mainly focused on the characterization of the cell responses that happen after the activation of the GCKIII proteins of the Ste20 group of kinases. In doing so we and others have seen that these kinases are implicated in regulating cell metabolism and in the orderly development of the microvasculature in stressful situations. At present, we are studying the implication of GCKIII in the alteration of the microvasculature of the central nervous system as it is the case in the cerebral cavernous malformation disease and in the resistance to insulin and the alterations that follow in the liver.

Research Lines

  • To dissect the signalling pathways of stress protein kinases, especially those of the GCK III subfamily.
  • To uncover the role of the stress protein kinases in cell biology identity and its homeostasis.
  • To identify the role of stress protein kinases in pathophysiology. At present working on the role of GCK III proteins in cerebral cavernous malformations development and liver metabolic alterations.



Mar García Colomer
PhD student

Selected publications

The GCKIII kinases STK24 and STK25 inhibit cavernoma development

Miriam Sartages, Mar García-Colomer, Cristina Iglesias, Brian W Howel, Manuel Macía, Patricia Peña, Celia M. Pombo* and Juan Zalvide*

High levels of receptor tyrosine kinases in CCM3-deficient cells increase their susceptibility to tyrosine kinase inhibition

M. Sartages, E. Floridia, M. García-Colomer, C. Iglesias, M. Macía, P. Peñas, P-O Couraud, I. A. Romero, B. Weksler, C. M. Pombo, Juan Zalvide

MST Kinases and Metabolism

Pombo, CM; Iglesias, C; Sartages, M; Zalvide, JB
The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet.
Iglesias, Cristina; Floridia, Ebel; Sartages, Miriam; Porteiro, Begona; Fraile, Maria; Guerrero, Ana; Santos, Diana; Cunarro, Juan; Tovar, Sulay; Nogueiras, Ruben; Pombo, Celia M; Zalvide, Juan

The Cerebral Cavernous Malformation 3 gene is necessary for senescence induction

Guerrero A., Iglesias C. Raguz S., Floridia E., Gil J., Pombo CM, Zalvide J.

A novel cardioprotective p38-MAPK/mTOR pathway

Gonzalo Hernández, Hind Lal, Miguel Fidalgo, Ana Guerrero, Juan Zalvide, Thomas Force, Celia M Pombo

Selected Results


National project(s)

Cavernomas and GCKIII proteins. From pathogenesis to therapeutics.
REF: PID2021-123365OB-I00Duration: -
PI: Celia Pombo and Juan Zalvide


Rede de Animais Transxénicos de Galicia (RATGA)