Endocrine Oncology (EnOn)
The group is working in two lines of research about human breast cancer. In the first one, we study the involvement of the POU1F1 transcription factor (also known as Pit-1) in the pathogenesis of breast cancer. Specifically, how the POU1F1 expressed by tumor cells could interact with stromal cells, and the role of POU1F1 in breast cell plasticity, including breast tumor cells, normal epithelial cells, and breast stem cells. In the second line, we evaluate if no-calcemic vitamin D analogs and retinoid analogs could be used for breast cancer treatment.
- Role of the POU1F1 transcription factor in breast cell plasticity
- Vitamin D and retinoid analogs in breast cancer treatment
Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis
POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages
POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation
Design, Synthesis, Biological Activity, and Structural Analysis of Novel Des-C-Ring and Aromatic-D-Ring Analogs of 1α,25-Dihydroxyvitamin D3.