Molecular Medicine Programme | Cardiovascular
Laboratory for vascular biology
Juan Bautista Zalvide Torrente
Group Leader | Full Professor
juan.zalvide@usc.es
Lab: P1L6
Field of knowledge
Biology of vascular malformations, particularly cerebral cavernous malformations (CCMs)
Research Lines
- Role of GCKIII proteins in cavernoma development and MAP Kinase signaling.
- Pharmacological therapies for CCMs.
Members
Selected publications
High levels of receptor tyrosine kinases in CCM3-deficient cells increase their susceptibility to tyrosine kinase inhibition
The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet.
Hepatic p63 regulates steatosis via IKK beta/ER stress (vol 8, 15111, 2017)
A Functional link between ampk and orexin mediates the effect of BMP8B on energy balance.
The Cerebral Cavernous Malformation 3 gene is necessary for senescence induction
Cerebral Cavernous Malformations: from CCM genes to endothelial cell homeostasis.
Selected Results
Projects
National project(s)
Cavernomas and GCKIII proteins. From pathogenesis to therapeutics.
PI: Celia Pombo and Juan Zalvide
AGENCIA ESTATAL DE INVESTIGACION