Molecular Medicine Programme | Cardiovascular

Laboratory for vascular biology

Juan Bautista Zalvide Torrente

Group Leader | Full Professor

juan.zalvide@usc.es

ORCID: 0000-0001-7645-156X

Lab: P1L6

Field of knowledge

Biology of vascular malformations, particularly cerebral cavernous malformations (CCMs)

Research Lines
Members
Selected publications
Selected Results
Projects
Alliances

Research Lines

Role of GCKIII proteins in cavernoma development and MAP Kinase signaling.
Pharmacological therapies for CCMs.

Members

José Emilio Martínez Rodríaguez

PhD student

Selected publications

The GCKIII kinases STK24 and STK25 inhibit cavernoma development

Miriam Sartages, Mar García-Colomer, Cristina Iglesias, Brian W Howel, Manuel Macía, Patricia Peña, Celia M. Pombo* and Juan Zalvide*

Stroke, 53(3):976-986.

High levels of receptor tyrosine kinases in CCM3-deficient cells increase their susceptibility to tyrosine kinase inhibition

M. Sartages, E. Floridia, M. García-Colomer, C. Iglesias, M. Macía, P. Peñas, P-O Couraud, I. A. Romero, B. Weksler, C. M. Pombo, Juan Zalvide

Biomedicines, 8(12), 624.

MST Kinases and Metabolism

Pombo, CM; Iglesias, C; Sartages, M; Zalvide, JB

ENDOCRINOLOGY, 2019 May 1;160(5):1111-1118

The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet.

Iglesias, Cristina; Floridia, Ebel; Sartages, Miriam; Porteiro, Begona; Fraile, Maria; Guerrero, Ana; Santos, Diana; Cunarro, Juan; Tovar, Sulay; Nogueiras, Ruben; Pombo, Celia M; Zalvide, Juan

, 2017 dec; 60 (12): 2453-2462

Hepatic p63 regulates steatosis via IKK beta/ER stress (vol 8, 15111, 2017)

Porteiro, B; Fondevila, MF; Delgado, TC; Iglesias, C; Imbernon, M; Iruzubieta, P; Crespo, J; Zabala-Letona, A; Ferno, J; Gonzalez-Teran, B; Matesanz, N; Hernandez-Cosido, L; Marcos, M; Tovar, S; Vidal, A; Sanchez-Ceinos, J; Malagon, MM; Pombo, C; Zalvide, J; Carracedo, A; Buque, X; Dieguez, C; Sabio, G; Lopez, M; Aspichueta, P; Martinez-Chantar, ML; Nogueiras, R

Nature Communications, 2017 jun; 8

A Functional link between ampk and orexin mediates the effect of BMP8B on energy balance.

Martins L, Seoane-Collazo P, Contreras C, González-García I, Martínez-Sánchez N, González F, Zalvide J, Gallego R, Diéguez C, Nogueiras R, Tena-Sempere M & López M

Cell Reports (2016)16:2231-42

The Cerebral Cavernous Malformation 3 gene is necessary for senescence induction

Guerrero A., Iglesias C. Raguz S., Floridia E., Gil J., Pombo CM, Zalvide J.

Aging Cell. 14(2):274-83.

Cerebral Cavernous Malformations: from CCM genes to endothelial cell homeostasis.

Fischer, J. Zalvide, E. Faurobert, C. Albiges-Rizo, E. Tournier-Lasserve.

Trends in Molecular Medicine. 19(5):302-8.