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Mechanisms of Disease

Laboratory for vascular biology

Juan Bautista Zalvide Torrente
Group Leader | Full Professor
juan.zalvide@usc.es
 
Lab: P1L6
Field of knowledge

Biology of vascular malformations, particularly cerebral cavernous malformations (CCMs)

Research Lines

  • Role of GCKIII proteins in cavernoma development and MAP Kinase signaling.
  • Pharmacological therapies for CCMs.

Members

 

José Emilio Martínez Rodríaguez
PhD student

Selected publications

The GCKIII kinases STK24 and STK25 inhibit cavernoma development

Miriam Sartages, Mar García-Colomer, Cristina Iglesias, Brian W Howel, Manuel Macía, Patricia Peña, Celia M. Pombo* and Juan Zalvide*

High levels of receptor tyrosine kinases in CCM3-deficient cells increase their susceptibility to tyrosine kinase inhibition

M. Sartages, E. Floridia, M. García-Colomer, C. Iglesias, M. Macía, P. Peñas, P-O Couraud, I. A. Romero, B. Weksler, C. M. Pombo, Juan Zalvide

MST Kinases and Metabolism

Pombo, CM; Iglesias, C; Sartages, M; Zalvide, JB
The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet.
Iglesias, Cristina; Floridia, Ebel; Sartages, Miriam; Porteiro, Begona; Fraile, Maria; Guerrero, Ana; Santos, Diana; Cunarro, Juan; Tovar, Sulay; Nogueiras, Ruben; Pombo, Celia M; Zalvide, Juan
Hepatic p63 regulates steatosis via IKK beta/ER stress (vol 8, 15111, 2017)
Porteiro, B; Fondevila, MF; Delgado, TC; Iglesias, C; Imbernon, M; Iruzubieta, P; Crespo, J; Zabala-Letona, A; Ferno, J; Gonzalez-Teran, B; Matesanz, N; Hernandez-Cosido, L; Marcos, M; Tovar, S; Vidal, A; Sanchez-Ceinos, J; Malagon, MM; Pombo, C; Zalvide, J; Carracedo, A; Buque, X; Dieguez, C; Sabio, G; Lopez, M; Aspichueta, P; Martinez-Chantar, ML; Nogueiras, R

A Functional link between ampk and orexin mediates the effect of BMP8B on energy balance.

Martins L, Seoane-Collazo P, Contreras C, González-García I, Martínez-Sánchez N, González F, Zalvide J, Gallego R, Diéguez C, Nogueiras R, Tena-Sempere M & López M

The Cerebral Cavernous Malformation 3 gene is necessary for senescence induction

Guerrero A., Iglesias C. Raguz S., Floridia E., Gil J., Pombo CM, Zalvide J.

Cerebral Cavernous Malformations: from CCM genes to endothelial cell homeostasis. 

Fischer, J. Zalvide, E. Faurobert, C. Albiges-Rizo, E. Tournier-Lasserve.

Selected Results

Projects

National project(s)

Cavernomas and GCKIII proteins. From pathogenesis to therapeutics.
REF: PID2021-123365OB-I00Duration: -
PI: Celia Pombo and Juan Zalvide
AGENCIA ESTATAL DE INVESTIGACION

Alliances

Rede de Animais Transxénicos de Galicia (RATGA)