Virus and Cancer (VICA)
Our interest is the study of the virus-host cell interaction, and the contribution of ubiquitin-like proteins to this interplay.
Research Lines
We have two fundamental lines of research:
- The study of the exploitation of cellular machinery by viruses in order to favor their replication.
- The study of the cellular molecular pathways relevant for the control of viral replication and cell proliferation.
We are especially interested in the role that small ubiquitin-like proteins (SUMO) play in both processes. Our aim is to identify those mechanisms that regulate both viral replication and the development of proliferative diseases, to expand the knowledge of the relationship between viruses and cancer and to discover potential prophylactic or therapeutic targets for intervention.
Members
Selected publications
eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production.
SUMOylation modulates the stability and function of PI3K- p110 beta.
Expression of the Ebola Virus VP24 Protein Compromises the Integrity of the Nuclear Envelope and Induces a Laminopathy-Like Cellular Phenotype.
Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function