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Programa de Medicina Molecular | Cáncer

Endocrine Oncology (EnOn)

Román Pérez-Fernández
Group Leader | Full Professor
roman.perez.fernandez@usc.es
 
Lab: P1L2
Área de conocimiento

The group is working in two lines of research about human breast cancer. In the first one, we study the involvement of the POU1F1 transcription factor (also known as Pit-1) in the pathogenesis of breast cancer. Specifically, how the POU1F1 expressed by tumor cells could interact with stromal cells, and the role of POU1F1 in breast cell plasticity, including breast tumor cells, normal epithelial cells, and breast stem cells. In the second line, we evaluate if no-calcemic vitamin D analogs and retinoid analogs could be used for breast cancer treatment.

Líneas de investigación

  1. Role of the POU1F1 transcription factor in breast cell plasticity
  2. Vitamin D and retinoid analogs in breast cancer treatment

Miembros

Maria Efigenia Arias Baltar
Research Associate
mefigenia.arias.baltar@usc.es
Samuel Seoane Ruzo
Research Associate
samuel.seoane@usc.es

 

Leandro Avila Concepción
PhD student
Sandra Rodriguez Gonzalez
PhD student

Publicaciones seleccionadas

Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis

I Ben-Batalla, S Seoane, T Garcia-Caballero, R Gallego, M Macia, LO Gonzalez, F Vizoso, R Perez-Fernandez.
Breast cancer metastasis to liver and lung is facilitated by Pit-1-CXCL12-CXCR4 axis
Martinez-Ordonez, Anxo; Seoane, Samuel; Cabezas, Pablo; Eiro, Noemi; Sendon-Lago, Juan; Macia, Manuel; Garcia-Caballero, Tomas; Gonzalez, Luis O.; Sanchez, Laura; Vizoso, Francisco; Perez-Fernandez, Roman
Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists
Gogoi, Pranjal; Seoane, Samuel; Sigueeiro, Rita; Guiberteau, Thierry; Maestro, Miguel A.; Perez-Fernandez, Roman; Rochel, Natacha; Mourino, Antonio

POU1F1 transcription factor promotes breast cancer metastasis via recruitment and polarization of macrophages

Seoane, S; Martinez-Ordonez, A; Eiro, N; Cabezas-Sainz, P; Garcia-Caballero, L; Gonzalez, LO; Macia, M; Sanchez, L; Vizoso, F; Perez-Fernandez, R

POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation

Anxo Martínez-Ordoñez, Samuel Seoane, Leandro Avila, Noemi Eiro, Manuel Macía, Efigenia Arias, Fabio Pereira, Tomas García-Caballero, Noemi Gómez-Lado, Pablo Aguiar, Francisco Vizoso & Román Perez-Fernandez

Design, Synthesis, Biological Activity, and Structural Analysis of Novel Des-C-Ring and Aromatic-D-Ring Analogs of 1α,25-Dihydroxyvitamin D3.

S Seoane, P Gogoi, A Zárate-Ruíz, C Peluso-Iltis, S Peters, T Guiberteau, M Maestro, R Perez-Fernandez, N Rochel, A Mouriño.

Resultados seleccionados

Proyectos

UE project(s)

Innovative ligands for nuclear receptors to eradicate cancer relapse (eRaDicate)
REF: 101119427Duration: -
PI: Román Perez-Fernandez
Marie Skłodowska-Curie – ITNMarie Skłodowska-Curie Actions (MSCA)

National project(s)

Plasticity in breast cancer: role of POU1F1 and vitamin D
REF: PID2021-127394OB-I00Duration: -
PI: R Perez-Fernandez
AGENCIA ESTATAL DE INVESTIGACION

Patentes

Análogos de Vitamina D con interés farmacéutico
Application Nº: US9663429B2
Human Uterine Cervical Stem Cell population and uses thereof
Application Nº: PCT/EP2014/053508
Sila-Analogues of Vitamin D compounds, method of producing said compounds and uses thereof
Application Nº: PCT/IB2022/052839
A novel class of vitamin D receptor ligands bearing carborane moiety
Application Nº: Pending, June 2022