Publicaciones

2026

Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis.

Novoa E, Parracho T, Inderhees J, Rodriguez A, Riobello C, Iglesias-Moure J, Fernández-Iglesias A, Martinez-Martinez S, Senra A, Seoane S, Fondevila M, Iglesias C, Cabaleiro A, da Silva Lima N, Dorta V, López-Picallo B, Ramos-Lage L, Woodhoo A, Fidalgo M, Martínez-Chantar ML, Cubero FJ, López M, Dieguez C, Guallar D, Prevot V, Schwabe RF, Frühbeck G, Crespo J, Varela-Rey M, Gonzalez-Rellan MJ, Gracia-Sancho J, Iruzubieta P, Schwaninger M, Nogueiras R.

Cell Metab. 2026 Feb 23:S1550-4131(26)00016-1.

Epitranscriptomics & Ageing , Gene Regulatory Control in Disease , Liver Metabolism and Disorders Laboratory, Molecular Metabolism

LEAP2 acts in hepatocytes and at central level, alleviates steatosis and inflammation but resistance in obese and aging

Miguéns MV, Quintela-Vilariño C, Casado S, de Oliveira-Diz T, Müller TD, Nogueiras R, Diéguez C, Tovar S

Life Sci. 2026 Mar 1;388:124219

Diabesity, Functional Obesomics , Molecular Metabolism

Transient steatosis reprograms MDMs for liver repair

Woodhoo A, Varela-Rey M

Nat Metab. 2026 Mar 11

Gene Regulatory Control in Disease , Liver Metabolism and Disorders Laboratory

2025

Ceramides in the central control of metabolism

López M, Diéguez C, Tena-Sempere M & González-García I.

Trends in Endocrinology and Metabolism (2025) 36:11-14

Functional Obesomics , NeurObesity, Neuroendocrine Regulation of Metabolism

Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis

Zumalave S, Santamarina M, P Espasandín N, Zamora J, Garcia-Souto D, Temes J, Baker TM, Rodríguez-Castro J, Otero P, Pequeño-Valtierra A, Otero I, Oitabén A, Álvarez EG, Díaz-Arias I, Martínez-Fernández M, Blanco MG, Van Loo P, Cristofari G, Rodriguez-Martin B, Tubio JMC

Science. 2026 Feb 26:eaee4513

Mobile Genomes