Fluorescent sensors and biomarkers for improving drug selection in neurodegenerative diseases

About

Our research is focused on using chemical tools, including inorganic nanoparticles or Quantum Dots, to understand biological mechanisms in pathological conditions of neurodegenerative diseases. Our goal is to better characterize the complex mechanisms of neuroprotective agents in models derived from patients to find effective drugs with a high potential for clinical transfer. In parallel, we develop innovative strategies to discover drugs against Alzheimer's disease and effectively increase their brain permeability in combination with organic nanoparticles.  

Bio

Valle obtained her BSc in Chemistry in 2008. That year she joined the Medicinal Chemistry Institute at CSIC with Prof. A. Martínez to develop neurogenic and neuroprotective drugs for neurodegenerative diseases. In 2012 she obtained her PhD and in 2013 she joined The Scripps Research Institute in La Jolla with Prof. P. Dawson. She focussed on the development of Quantum Dot nanoparticles, peptide synthesis and conjugation. In 2016 she returned to Spain as a Juan de la Cierva fellow at the Centre for Biological research from CSIC. In 2018, she established her own research group thanks to a Junior Leader fellowship from la Caixa. In 2021, she moved her lab to IMDEA Nanociencia, thanks to the Ramon y Cajal fellowship, and is now head of the lab of Biosensors in Neuroscience.

Host PI: María José Alonso. Nanomedicine and Drug Delivery group, CiMUS

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