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Programa de Mecanismos Moleculares | Cancro

Neoplasia & Endocrine Differentiation

Clara Álvarez Villamarín
Clara Álvarez Villamarín
Group Leader | Full professor
clara.alvarez@usc.es
ORCID: 0000-0003-1500-4058
 
Lab: P0L5
Área de coñecemento

The group is focused on endocrine physiology and patho-physiology of the pituitary and thyroid glands. To this purpose, it includes basic investigators, surgeon and pathologists.

Liñas de investigación

  • We study Thyroid cancer and neoplasia, from Papillary (PTC) and Follicular Thyroid Cancer (FTC) the most common differentiated types to the most aggressive like Poorly Differentiated Thyroid Cancer (PDTC) or Anaplastic Thyroid Cancer. TIROCHUS a collection of surgical surplus and cultures donated from the patients make possible this research.

     

  • We study cellular mechanisms explaining differentiation from the niche of adult stem cells into secretory types of cells both in the adenopituitary (somatotrophs, lactotrophs, thyrotrophs, corticotrophs and gonadotrophs) or in the thyroid (follicular, medullary). REMAH a collection of surgical surplus donated from the patients contributes essentially to this research.

     

  • We innovate into new technology to study hormone-dependent human cancer, including breast and prostate cancer patented research to support this endeavour.

Membros

Photo group member
Miguel Ángel Chenlo Miranda
Postdoctoral research associate
miguelangel.chenlo@usc.es

 

Sihara Pérez Romero
Research Specialist Technician
María del Carmen Suarez Fariña
Research Specialist Technician
Jesuina Arcangela Graça Fonseca
PhD student
Cristina Cardona Barreña
FPI fellowship
José Tubio Viturro
PhD student

Publicacións seleccionadas

Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly

Chenlo, M; Rodriguez-Gomez, IA; Serramito, R; Garcia-Rendueles, AR; Villar-Taibo, R; Fernandez-Rodriguez, E; Perez-Romero, S; Suarez-Farina, M; Garcia-Allut, A; Cabezas-Agricola, JM; Rodriguez-Garcia, J; Lear, PV; Alvarez-San Martin, RM; Alvarez-Escola, C; Bernabeu, I; Alvarez, CV
EBIOMEDICINE, 2019 May;43:537-552
Rewiring of the apoptotic TGF-beta-SMAD/NF kappa B pathway through an oncogenic function of p27 in human papillary thyroid cancer
Garcia-Rendueles, A. R.; Rodrigues, J. S.; Garcia-Rendueles, M. E. R.; Suarez-Farina, M.; Perez-Romero, S.; Barreiro, F.; Bernabeu, I.; Rodriguez-Garcia, J.; Fugazzola, L.; Sakai, T.; Liu, F.; Cameselle-Teijeiro, J.; Bravo, S. B.; Alvarez, C. V.
ONCOGENE,, 2017 feb; 36 (5): 652-666
Early evolutionary divergence between papillary and anaplastic thyroid cancers
Capdevila, J.; Mayor, R.; Mancuso, F. M.; Iglesias, C.; Caratu, G.; Matos, I.; Zafon, C.; Hernando, J.; Petit, A.; Nuciforo, P.; Cameselle-Teijeiro, J. M.; Alvarez, C.;
Annals of Oncology,, 2016, 29 (6), 1454-1460
The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGF beta and Activin pathways
Garcia, M; Barrio, R; Garcia-Lavandeira, M; Garcia-Rendueles, AR; Escudero, A; Diaz-Rodriguez, E; Del Blanco, DG; Fernandez, A; de Rijke, YB; Vallespin, E; Nevado, J; Lapunzina, P; Matre, V; Hinkle, PM; Hokken-Koelega, ACS; de Miguel, MP; Cameselle-Teijeiro, JM; Nistal, M; Alvarez, CV; Moreno, JC
SCIENTIFIC REPORTS,, 2017 mar; 7
The Molecular Registry of Pituitary Adenomas (REMAH): A bet of Spanish Endocrinology for the future of individualized medicine and translational research.
Luque RM, Ibáñez-Costa A, Sánchez-Tejada L, Rivero-Cortés E, Robledo M, Madrazo-Atutxa A, Mora M, Álvarez CV, Lucas-Morante T, Álvarez-Escolá C, Fajardo C, Castaño L, Gaztambide S, Venegas-Moreno E, Soto-Moreno A, Gálvez MÁ, Salvador J, Valassi E, Webb SM, Picó A, Puig-Domingo M, Gilabert M, Bernabéu I, Marazuela M, Leal-Cerro A, Castaño JP; investigadores del REMAH..
Endocrinol Nutr. , 2016 Jun-Jul;63(6):274-84.

Resultados seleccionados

Proxectos

Proxecto(s) activo(s)

Proxectos nacionais

CONSOLIDACIÓN E ESTRUTURACIÓN 2025 GRC GI-1233 Investigacións biomédicas - GIBIOMED
REF: ED431C 2025/24Duration: -
PI: Carlos Diéguez González
CONSELLERIA DE EDUCACION, UNIVERSIDADE E FORMACION PROFESIONAL
Mecanismos de mitosis y recambio celular en Tiroides Normal, Hiperplasia, y Cáncer
REF: PID2022-140149OB-I00Duration: -
PI: Clara Álvarez Villamarín
AGENCIA ESTATAL DE INVESTIGACION
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GENERACIÓN DE CONOCIMIENTO 2022 - Proyectos investigación orientada

Proxecto(s) finalizado(s)

Proxectos nacionais

Terapia dsRNAi para Carcinoma Anaplásico de Tiroides
Duration: -
PI: Clara Álvarez Villamarín
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Convocatorias Propias de I+D

Mecanismos de proliferación y recambio celular de células endocrinas normales y cancerosas de la Tiroides y la Hipófisis - RETOS 2019
REF: PID2019-110437RB-I00Duration: -
PI: María Clara Álvarez Villamarín
AGENCIA ESTATAL DE INVESTIGACION

Alianzas

ETA
Thyroid Cancer Group (TCg) of the European Thyroid Association

Patentes

Cell lines and the use thereof for identifying drugs for thyroid carcinoma
Application Nº: ES201031322
Isolation of multipotent hypophysary cells and in vitro differentiation thereof
Application Nº: WO2009ES70530 20091125
Compuestos y métodos para el tratamiento del cáncer
Application Nº: P201930743
Marcadores de pronóstico, diana terapeútica y tratamiento para la acromegalia
Application Nº: EP19382828