Precision Medicine

Neoplasia & Endocrine Differentiation

Clara Álvarez Villamarín

Group Leader | Full professor

clara.alvarez@usc.es

Lab: P0L5

Field of knowledge

The group is focused on endocrine physiology and patho-physiology of the pituitary and thyroid glands. To this purpose, it includes basic investigators, surgeon and pathologists.

Research Lines
Members
Selected publications
Selected Results
Alliances
Patents

Research Lines

We study Thyroid cancer and neoplasia, from Papillary (PTC) and Follicular Thyroid Cancer (FTC) the most common differentiated types to the most aggressive like Poorly Differentiated Thyroid Cancer (PDTC) or Anaplastic Thyroid Cancer. TIROCHUS a collection of surgical surplus and cultures donated from the patients make possible this research.
We study cellular mechanisms explaining differentiation from the niche of adult stem cells into secretory types of cells both in the adenopituitary (somatotrophs, lactotrophs, thyrotrophs, corticotrophs and gonadotrophs) or in the thyroid (follicular, medullary). REMAH a collection of surgical surplus donated from the patients contributes essentially to this research.
We innovate into new technology to study hormone-dependent human cancer, including breast and prostate cancer patented research to support this endeavour.

Members

Miguel Ángel Chenlo Miranda

Postdoctoral research associate

miguelangel.chenlo@usc.es

Sihara Pérez Romero

Research Specialist Technician

María del Carmen Suarez Fariña

Research Specialist Technician

Jesuina Arcangela Graça Fonseca

PhD student

Cristina Cardona Barreña

FPI fellowship

José Tubio Viturro

PhD student

Selected publications

Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly

Chenlo, M; Rodriguez-Gomez, IA; Serramito, R; Garcia-Rendueles, AR; Villar-Taibo, R; Fernandez-Rodriguez, E; Perez-Romero, S; Suarez-Farina, M; Garcia-Allut, A; Cabezas-Agricola, JM; Rodriguez-Garcia, J; Lear, PV; Alvarez-San Martin, RM; Alvarez-Escola, C; Bernabeu, I; Alvarez, CV

EBIOMEDICINE, 2019 May;43:537-552

Rewiring of the apoptotic TGF-beta-SMAD/NF kappa B pathway through an oncogenic function of p27 in human papillary thyroid cancer

Garcia-Rendueles, A. R.; Rodrigues, J. S.; Garcia-Rendueles, M. E. R.; Suarez-Farina, M.; Perez-Romero, S.; Barreiro, F.; Bernabeu, I.; Rodriguez-Garcia, J.; Fugazzola, L.; Sakai, T.; Liu, F.; Cameselle-Teijeiro, J.; Bravo, S. B.; Alvarez, C. V.

ONCOGENE,, 2017 feb; 36 (5): 652-666

Early evolutionary divergence between papillary and anaplastic thyroid cancers

Capdevila, J.; Mayor, R.; Mancuso, F. M.; Iglesias, C.; Caratu, G.; Matos, I.; Zafon, C.; Hernando, J.; Petit, A.; Nuciforo, P.; Cameselle-Teijeiro, J. M.; Alvarez, C.;

Annals of Oncology,, 2016, 29 (6), 1454-1460

The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGF beta and Activin pathways

Garcia, M; Barrio, R; Garcia-Lavandeira, M; Garcia-Rendueles, AR; Escudero, A; Diaz-Rodriguez, E; Del Blanco, DG; Fernandez, A; de Rijke, YB; Vallespin, E; Nevado, J; Lapunzina, P; Matre, V; Hinkle, PM; Hokken-Koelega, ACS; de Miguel, MP; Cameselle-Teijeiro, JM; Nistal, M; Alvarez, CV; Moreno, JC

SCIENTIFIC REPORTS,, 2017 mar; 7

The Molecular Registry of Pituitary Adenomas (REMAH): A bet of Spanish Endocrinology for the future of individualized medicine and translational research.

Luque RM, Ibáñez-Costa A, Sánchez-Tejada L, Rivero-Cortés E, Robledo M, Madrazo-Atutxa A, Mora M, Álvarez CV, Lucas-Morante T, Álvarez-Escolá C, Fajardo C, Castaño L, Gaztambide S, Venegas-Moreno E, Soto-Moreno A, Gálvez MÁ, Salvador J, Valassi E, Webb SM, Picó A, Puig-Domingo M, Gilabert M, Bernabéu I, Marazuela M, Leal-Cerro A, Castaño JP; investigadores del REMAH..

Endocrinol Nutr. , 2016 Jun-Jul;63(6):274-84.