Neoplasia & Endocrine Differentiation
The group is focused on endocrine physiology and patho-physiology of the pituitary and thyroid glands. To this purpose, it includes basic investigators, surgeon and pathologists.
We study Thyroid cancer and neoplasia, from Papillary (PTC) and Follicular Thyroid Cancer (FTC) the most common differentiated types to the most aggressive like Poorly Differentiated Thyroid Cancer (PDTC) or Anaplastic Thyroid Cancer. TIROCHUS a collection of surgical surplus and cultures donated from the patients make possible this research.
We study cellular mechanisms explaining differentiation from the niche of adult stem cells into secretory types of cells both in the adenopituitary (somatotrophs, lactotrophs, thyrotrophs, corticotrophs and gonadotrophs) or in the thyroid (follicular, medullary). REMAH a collection of surgical surplus donated from the patients contributes essentially to this research.
- We innovate into new technology to study hormone-dependent human cancer, including breast and prostate cancer patented research to support this endeavour.
Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly