The thousand metabolic faces of mitochondria

About:

Mitochondria play key roles in cell homeostasis, and many of these functions are not strictly related to energy production but in many other territories such as in ROS production, cellular proliferation, immune responses or cell death. In this talk, I will analyze the implications of mitochondrial dynamics in tissue and cell homeostasis, and I will detail some examples taken from the study of the mitochondrial protein Mitofusin 2.
 

Bio:

Antonio Zorzano is  Full Professor of Biochemistry and Molecular Biology at the University of Barcelona, Director of Complex metabolic diseases and mitochondria laboratory at the IRB Barcelona, and member of CIBERDEM. Professor Zorzano received his PhD in Biology at the University of Barcelona, and did postdoctoral studies with Emilio Herrera (Hospital Ramon y Cajal, Madrid), Neil Ruderman (Boston University Medical Center), and Paul Pilch (Boston University Medical School). He was Visiting Professor at Boston University Medical School. He has supervised 42 Ph.D. theses, and has coordinated  international consortia funded by different European agencies. He is co-inventor of 23 patents, and has published over 360 scientific articles (more than 48,000 citations), with key discoveries published in leading journals, and an h-index of 99 (Google Scholar). He has been founder of biotechnological companies in Spain and UK. 
Professor Zorzano’s research focuses on the regulation of metabolism and its interplay with insulin resistance, obesity, type 2 diabetes, and liver diseases. His current interest links metabolism with mitochondrial dynamics, autophagy, and mitochondrial stress.  A global goal of his group is to identify and validate molecular targets that permit the prevention or treatment of metabolic diseases by using cell-based systems, genetically modified mice, and translational approaches.

Host PI: Ashwin Woodhoo. Gene Regulatory Control in Disease Group, CiMUS.

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